C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) C07K 16/22 (2006.01) C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2263143
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as "KGF-2" also formerly known as Fibroblast Growth Factor 12 (FGF-12). The invention also relates to inhibiting the action of such polypeptides. This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.
La présente invention concerne des polynucléotides récemment identifiés, des polypeptides codés par de tels polynucléotides, l'utilisation de tels polynucléotides et polypeptides, ainsi que la production de tels polynucléotides et polypeptides. En l'occurrence, le polypeptide de la présente invention est un facteur de croissance des kératinocytes, parfois désigné ci-après "KGF-2" (pour "Keratinocyte Growth Factor-2"), jusqu'à présent connu comme facteur de croissance des fibroblastes 12 ou "FGF-12" (pour "Fibroblast Growth Factor-12"). L'invention concerne également l'inhibition de l'action de tels polypeptides. L'invention concerne en outre l'utilisation thérapeutique du KGF-2 pour favoriser ou accélérer la guérison de lésions. L'invention concerne enfin de nouvelles formes mutantes du KGF-2 qui font preuve d'une activité renforcée, d'une stabilité accrue, d'un rendement supérieur ou d'une meilleure solubilité.
Coleman Timothy A.
Duan Roxanne
Gentz Reiner L.
Jimenez Pablo
Mendrick Donna
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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