Keratinocyte growth factor analogs

Details Keratinocyte growth factor analogs Keratinocyte growth factor analogs

C - Chemistry, Metallurgy

12

N

C12N 15/18 (2006.01) A61K 38/18 (2006.01) C07K 14/50 (2006.01) A61K 38/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2202390

Novel analogs of proteins of KGF are provided comprising a charge-change by the deletion or substitution of one or more of amino acid residues 41-154 (amino acids 72-185 of SEQ ID NO:2). These analogs are more stable than the corresponding parent molecule KGF.

La présente invention se rapporte à de nouveaux analogues de protéines du facteur de croissance des kératinocytes, comportant une modification de charge obtenue par la délétion ou la substitution d'un ou de plusieurs des résidus aminoacides 41-154 de la figure 2 (aminoacides 72-185, ID. SEQ. N DEG 2). Ces analogues sont plus stables que le facteur de croissance des kératinocytes de la molécule mère correspondante.

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