Keratinocytes expressing exogenous angiogenic growth factors

Details Keratinocytes expressing exogenous angiogenic growth factors Keratinocytes expressing exogenous angiogenic growth factors

A - Human Necessities

61

K

A61K 35/36 (2006.01) C12N 5/071 (2010.01) A61K 38/18 (2006.01) A61K 48/00 (2006.01) A61L 27/38 (2006.01) A61L 27/60 (2006.01) A61K 35/12 (2006.01) C07K 14/515 (2006.01)

Patent

CA 2483547

The present invention relates to in vitro cultured skin tissue, and in particular to cultured skin tissue comprising exogenous genes encoding angiogenic growth factors. In some embodiments, the keratinocytes express exogenous angiopoietin-1 or a member of the VEGF family, preferably VEGF-A. In particularly preferred embodiments, the keratinocytes are incorporated into cultured skin tissue.

L'invention concerne un tissu cutané cultivé in vitro et notamment un tissu cutané cultivé comprenant des gènes exogènes codant pour des facteurs de croissance angiogéniques. Dans certains modes de réalisation, les kératinocytes expriment l'angiopoïétine-1 exogène ou un élément de la famille VEGF, de préférence VEGF-A. Dans des modes de réalisation préférés, les kératinocytes sont incorporés dans le tissu cutané cultivé.

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