Ketolide antibiotics

Details Ketolide antibiotics Ketolide antibiotics

C - Chemistry, Metallurgy

07

H

C07H 17/08 (2006.01) A61K 31/7048 (2006.01) A61P 31/04 (2006.01) A61P 33/02 (2006.01)

Patent

CA 2359708

This invention relates to compounds of formula (1) and to pharmaceutically acceptable salts and solvates thereof wherein X1, X2, R2, R8, R9, R10 and R11 are as defined herein. The compounds of formula (1) are antibacterial and antiprotozoal agents that may be used to treat various bacterial and protozoal infections and disorders related to such infections. The invention also relates to pharmaceutical compositions containing the compounds of formula (1) and to methods of treating bacterial and protozoal infections by administering the compounds of formula (1).

Composés de formule (1) et sels et solvates desdits composés acceptables sur le plan pharmaceutique. Dans ladite formule, X<1>, X<2>, R<2>, R<8>, R<9>, R<10> et R<11> sont tels que définis dans le descriptif. Lesdits composés de formule (1) sont des agents antibactériens et antiprotozoaires qui peuvent être utilisés pour traiter diverses infections et protozooses, ainsi que les troubles liés à ces maladies. La présente invention concerne également des compositions pharmaceutiques contenant les composés de formule (1) et des méthodes de traitement d'infections bactériennes et de protozooses par administration desdits composés.

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