Ketone derivatives

Details Ketone derivatives Ketone derivatives

C - Chemistry, Metallurgy

07

D

C07D 307/54 (2006.01) A61K 31/00 (2006.01) A61K 38/05 (2006.01) C07C 271/22 (2006.01) C07C 311/06 (2006.01) C07C 311/19 (2006.01) C07C 317/28 (2006.01) C07C 323/41 (2006.01) C07C 323/59 (2006.01) C07C 323/60 (2006.01) C07D 207/337 (2006.01) C07D 213/32 (2006.01) C07D 213/56 (2006.01) C07D 213/89 (2006.01) C07D 235/06 (2006.01) C07D 261/08 (2006.01) C07D 263/20 (2006.01) C07D 263/32 (2006.01) C07D 277/26 (2006.01) C07D 277/30 (2006.01) C07D 295/13 (2006.01) C07D 307/38 (2006.01) C07D 307/42 (2006.01) C07D 30

Patent

CA 2072834

- 312 - Abstract of the Disclosure: A novel ketone derivative (I) which possesses a potent inhibitory activity against thiol protease such as papain, cathepsin B, cathepsin H, cathepsin L, calpain or the like with excellent properties regarding oral absorbance, tissue transference and cell membrane permeability, and are clinically useful in the treatment of various diseases such as muscular dystrophy, amyotrophy. Also provided are a process for producing the compound (I) and a pharmaceutical composition containing the same.

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