Ketone ligands for modulating the expression of exogenous...

Details Ketone ligands for modulating the expression of exogenous... Ketone ligands for modulating the expression of exogenous...

C - Chemistry, Metallurgy

07

C

C07C 49/04 (2006.01) A61K 31/12 (2006.01) A61K 31/16 (2006.01) A61K 31/18 (2006.01) C07C 49/20 (2006.01) C07C 49/527 (2006.01) C07C 69/00 (2006.01) C07C 225/02 (2006.01) C07C 229/02 (2006.01) C07C 233/31 (2006.01) C07C 233/76 (2006.01) C07C 235/46 (2006.01) C07C 235/48 (2006.01) C07C 235/50 (2006.01) C07C 235/54 (2006.01) C07C 237/00 (2006.01) C07C 237/32 (2006.01) C07C 271/20 (2006.01) C07C 275/24 (2006.01) C07C 311/20 (2006.01) C07D 207/14 (2006.01) C07D 211/56 (2006.01) C07D 211/58 (2006.01) C07D 309/14

Patent

CA 2489590

This invention relates to a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising: a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene. The ligands comprise a class of ketones.

L'invention concerne une méthode permettant de moduler l'expression de gènes exogènes, dans laquelle un complexe de récepteurs à l'ecdysone comprend: un domaine de liaison ADN; un domaine de liaison de ligand; un domaine de transactivation. Un ligand est mis en contact avec une construction ADN et comprend: le gène exogène et un élément de réponse; le gène exogène étant sous contrôle de l'élément de réponse et reliant le domaine de liaison ADN à l'élément de réponse, en présence du ligand, ce qui provoque une activation ou une suppression de ce gène. Les ligands de l'invention comprennent une classe de cétones.

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