C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 239/42 (2006.01) A61K 31/505 (2006.01) A61P 3/06 (2006.01)
Patent
CA 2750801
The present invention relates in general to the field of organic chemistry and in particular to the preparation of N- (4-(4-fluorophenyl)-6-isopropyl-5-methylpyrimidin-2-yl)-N- methylmethanesulfonamide (I), N-(4-(4-fluorophenyl)-5-(bro- momethyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide (II) and N-(4- (4-fluorophenyl)-5-(hydroxymethyl)-6- iso- propylpyrimidin-2-yl)-N-methylmethanesulfonamide (III), key intermediates in preparation of Rosuvastatin.
La présente invention concerne en général le domaine de la chimie organique et porte en particulier sur la préparation de N-(4-(4-fluorophényl)-6-isopropyl-5-méthylpyrimidin-2-yl)-N-méthylméthanesulfonamide (I), de N-(4-(4-fluorophényl)-5-(bromométhyl)-6-isopropylpyrimidin-2-yl)-N-méthylméthanesulfonamide (II) et de N-(4-(4-fluorophényl)-5-(hydroxyméthyl)-6-isopropylpyrimidin-2-yl)-N-méthylméthanesulfonamide (III), qui sont des intermédiaires clés dans la préparation de la rosuvastatine.
Casar Zdenko
Kosmrlj Janez
Goudreau Gage Dubuc
Lek Pharmaceuticals D.d.
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