C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01) C07H 21/02 (2006.01) C07H 21/04 (2006.01)
Patent
CA 2597330
The invention relates to compositions and methods for detection of nucleic acid sequences. The invention further relates to kit format of said compositions for detection of nucleic acid sequences. Oligonucleotide probes of the invention comprise a target binding sequence and a sequence at least partially complementary thereto, joined by an optional linker to form a hairpin structure in the absence of the target nucleic acid sequence. The probes of the invention comprise a pair of moieties that produce a detectable signal when the probe hybridizes to the target sequence.
L'invention concerne des compositions et des procédés de détection de séquences d'acides nucléiques. L'invention concerne également un format de kit pour ces compositions de détection de séquences d'acides nucléiques. Les sondes oligonucléotidiques selon l'invention comprennent une séquence de liaison à la cible et une séquence au moins partiellement complémentaire de celle-ci, reliées par un lieur facultatif afin de former une structure en épingle à cheveux en l'absence de la séquence d'acides nucléiques cible. Les sondes selon l'invention comprennent une paire de fractions produisant un signal détectable lorsque la sonde s'hybride à la séquence cible.
Firmin Andrew
Happe Scott
Sorge Joseph A.
Cassan Maclean
Stratagene California
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