Kifs as modifiers of the rho pathway and methods of use

Details Kifs as modifiers of the rho pathway and methods of use Kifs as modifiers of the rho pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/48 (2006.01)

Patent

CA 2629473

Human KIF23 genes are identified as modulators of the RHO pathway, and thus are therapeutic targets for disorders associated with defective RHO function. Methods for identifying modulators of RHO, comprising screening for agents that modulate the activity of KIF23 are provided.

Selon l'invention les gènes humains de la KIF 23 sont identifiés comme des modulateurs du passage des RHO, et ils sont considérés comme des cibles thérapeutiques pour des troubles associés à une défaillance des RHO. L'invention concerne également des procédés pour identifier des modulateurs des RHO, comprenant le criblage d'agents qui modulent l'activité de la KIF 23.

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