Kim-1 antagonists and use to modulate immune system

Details Kim-1 antagonists and use to modulate immune system Kim-1 antagonists and use to modulate immune system

C - Chemistry, Metallurgy

07

K

C07K 19/00 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61P 1/00 (2006.01) A61P 29/00 (2006.01) A61P 37/06 (2006.01) C07K 14/705 (2006.01) C07K 16/00 (2006.01)

Patent

CA 2512138

The use of KIM-1 antagonists to inhibit signaling between a T cell and a second cell, e.g., an antigen-presenting cell, is disclosed. Such inhibition is useful for treatment of diseases including various autoimmune diseases and graft-versus-host disease. Also disclosed is the use of a KIM-1 antagonist to inhibit secretion of IFN-.gamma. by lymphocytes or other immune cells in a mammal. Inhibition of IFN-.gamma. is useful for treatment of inflammatory diseases or disorders, e.g., inflammatory bowel disease.

Selon cette invention, des antagonistes de la molécule-1 associée à une lésion rénale (KIM-1) sont utilisés pour inhiber la signalisation entre un lymphocyte T et une seconde cellule, telle qu'une cellule présentatrice d'antigène. Cette inhibition sert au traitement de maladies telles que diverses maladies autoimmunes et la maladie du greffon contre l'hôte. Selon cette invention, un antagoniste de la molécule-1 associée à une lésion rénale est également utilisé pour inhiber la sécrétion d'IFN-.gamma. par les lymphocytes ou autres cellules immunitaires chez un mammifère. L'inhibition d'IFN-.gamma. sert au traitement de maladies ou de troubles inflammatoires, tels que la maladie intestinale inflammatoire.

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