C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/44 (2006.01) A61K 31/519 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2689090
The present invention provides a novel pyrazolo[3,4-d]pyrimidin-4-one, specifically a derivative of 1-(pyridin-4-yl)-pyrazolo[3,4-d]pyrimidin-4-one. This compound is a kinase inhibitor that shows unexpected anti-proliferative activity against cells, including against tumor cells, and anti-tumor activity in xenograft tumor models. The compound or a suitable salt or prodrug thereof is useful for the treatment of individuals suffering from a cancer or another proliferative disorder or disease.
L'invention concerne un nouveau composé de pyrazolo[3,4-d]pyrimidin-4-one, spécifiquement un dérivé de 1-(pyridin-4-yl)-pyrazolo[3,4-d]pyrimidin-4-one. Ce composé constitue un inhibiteur de kinases qui présente une activité antiproliférante inattendue contre certaines cellules, y compris des cellules tumorales, et une activité antitumorale dans des modèles de tumeur de xénogreffe. Ce composé, ou un sel ou un promédicament approprié de celui-ci, est utile pour traiter des sujets atteints d'un cancer ou d'un autre trouble proliférant ou d'une autre maladie proliférante.
Agennix Ag
Borden Ladner Gervais Llp
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