Kinase inhibitor scaffolds and methods for their preparation

Details Kinase inhibitor scaffolds and methods for their preparation Kinase inhibitor scaffolds and methods for their preparation

C - Chemistry, Metallurgy

07

D

C07D 473/34 (2006.01) A61K 31/52 (2006.01) C07D 239/42 (2006.01) C07D 239/94 (2006.01) C07D 241/20 (2006.01) C07D 241/44 (2006.01) C07D 473/16 (2006.01) C07D 473/18 (2006.01)

Patent

CA 2463563

General methods for the solution phase as well as solid phase synthesis of various substituted heteroaryls has been demonstrated. These substituted heteroaryls can be further elaborated by aromatic substitution with amines at elevated temperature or by anilines, boronic acids and phenols via palladium catalyzed cross-coupling reactions.

Cette invention concerne des méthodes générales faisant intervenir la synthèse en phase en solution et en phase solide de divers hétéroaryles substitués. Ces hétéroaryles substitués peuvent également être obtenus par substitution aromatique avec des amines à une température élevée ou par des anilines, des acides boroniques et des phénols par l'intermédiaire de réactions de couplage croisé catalysées par le palladium.

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