Kinase inhibitors

Details Kinase inhibitors Kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 213/40 (2006.01) A61K 31/4409 (2006.01) A61P 11/06 (2006.01) C07D 401/12 (2006.01) C07D 407/12 (2006.01) C07D 409/12 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2623500

The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1, R2, R3, R31, n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

La présente invention concerne des nouveaux inhibiteurs de la kinase AGC, en particulier des composés représentés par les formules I, II ou III, ou bien un stéréo-isomère, un tautomère, un racémique, un métabolite, un pro ou un pré-médicament, un sel, un hydrate ou un solvate de ces composés (I II III) où X, R1, R2, R3, R31, n, et m sont comme définis dans les revendications. Cette invention concerne plus spécifiquement des inhibiteurs ROCK et des compositions, en particulier pharmaceutiques, contenant de tels inhibiteurs et l'utilisation de ces inhibiteurs à des fins curatives ou prophylactiques.

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