Kinase inhibitors

Details Kinase inhibitors Kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2595514

The present invention relates to indazolyl (1;2,4) triazine compounds having the general structure of Formula (I); useful as protein kinase inhibitors, pharmaceutical compositions comprising such compounds, and methods of treatment using the compounds and compositions to treat conditions such as cancer and proliferative diseases or immunodeficiencies, cardiovascular diseases, endocrine disorders, Parkinson's disease, metabolic diseases, tumorigenesis, Alzheimer's disease, heart disease, diabetes, neurodegeneration, inflammation, kidney disease, atherosclerosis and airway disease. The substituents are defined in the claims.

L'invention concerne un composé ayant la structure générale de formule (I) ou un sel pharmaceutiquement acceptable, un solvate ou un ester de ce composé, servant au traitement de maladies, troubles ou états pathologiques tels que les immunodéficiences, les cancers, les maladies cardiovasculaires, les maladies endocrines, la maladie de Parkinson, les maladies métaboliques, la tumorigenèse, la maladie d'Alzheimer, les maladies cardiaques, le diabète, la neurodégénérescence, les inflammations, les maladies rénales, l'athérosclérose et les troubles des voies respiratoires.

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