Kinase inhibitors and methods for using the same

Details Kinase inhibitors and methods for using the same Kinase inhibitors and methods for using the same

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2668731

Compounds of formula (I): wherein R1, R2, R3 and R4 are as defined herein. Also disclosed are methods of making the compounds, pharmaceutical compositions, methods of using the compounds for treatment of p38 MAP kinase-mediated diseases, and methods of using the compounds for treatment of Raf kinase-mediated diseases.

L'invention concerne des composés représentés par la formule (I) dans laquelle R1, R2, R3 et R4 sont tels que définis ici. L'invention concerne également des procédés de fabrication des composés, des compositions pharmaceutiques, des méthodes d'utilisation des composés dans le traitement des maladies médiées par la MAP kinase p38, et des méthodes d'utilisation des composés dans le traitement des maladies médiées par la Raf kinase.

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