Kinase inhibitors and methods of use

Details Kinase inhibitors and methods of use Kinase inhibitors and methods of use

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61P 21/00 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2730106

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as P13 kinase. Also provided in the present invention are methods of using these compositions to modulate activ-ities of one or more of these kinases, especially for therapeutic appli-cations.

La présente invention concerne des entités ou des composés chimiques, et des compositions pharmaceutiques les contenant, qui sont capables de moduler certaines protéine kinases telles que mTor, les tyrosine kinases et/ou les kinases lipidiques telles que la PI3 kinase. La présente invention concerne également des procédés d'utilisation de ces compositions pour moduler des activités d'une ou de plusieurs de ces kinases, notamment pour des applications thérapeutiques.

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