C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 209/42 (2006.01) A61K 31/34 (2006.01) C07D 209/60 (2006.01) C07D 213/86 (2006.01) C07D 217/26 (2006.01) C07D 231/56 (2006.01) C07D 233/52 (2006.01) C07D 239/42 (2006.01) C07D 277/50 (2006.01) C07D 277/82 (2006.01) C07D 307/68 (2006.01) C07D 307/85 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2690410
Provided herein are Compounds having the following structure: formula (I) wherein A, L, X and ring B are as defined herein, compositions comprising an effective amount of a Compound and methods for treating or preventing cancer, hypoxia, diabetes, stroke, autoimmune disease or a condition treatable or preventable by inhibition of Chk2, the ATM-Chk2 pathway or RSK2 comprising administering an effective amount of a Compound to a patient in need thereof.
La présente invention concerne des composés présentant la structure suivante : formule (I) dans laquelle A, L, X et le cycle B sont tels que définis ici, des compositions contenant une quantité efficace du composé et des procédés destinés à traiter ou à prévenir le cancer, l'hypoxie, le diabète, les accidents vasculaires cérébraux, les maladies auto-immunes ou des états pathologiques susceptibles d'être traités ou prévenus par l'inhibition de Chk2, de la voie ATM-Chk2 ou de RSK2, consistant à administrer une quantité efficace d'un composé à un patient en ayant besoin.
Cardellina John
Colasanti Andrew
Cook Charles M.
Currens Michael
Jobson Andy
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
Provid Pharmaceuticals Inc.
The United States Of America As Represented By The Department Of Nih
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