A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/416 (2006.01) A61K 31/00 (2006.01) A61P 9/10 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 35/00 (2006.01) A61P 35/02 (2006.01) A61P 35/04 (2006.01) A61P 43/00 (2006.01)
Patent
CA 2584493
The invention pertains to inhibitors of various kinases (e.g. S/T kinases, Tyr kinases, etc.), which inhibitors are previously known as cyclin dependent kinase inhibitors (CDKs). As described herein, the inhibitors of this invention are capable of inhibiting various wild-type and mutant form kinases, including drug resistant forms of mutant kinases. Thus the subject kinase inhibitors are useful in treating a wide range of diseases / conditions associated with abnormal functions / excessive activities of the target kinases, including mutant kinases. The invention further provides methods for treating cancers, tumors and patients which are resistant or refractory to other therapeutic agents. Pharmaceutical compositions and packaged pharmaceuticals with instructions of these inhibitors, and methods of using these inhibitors are also provided.
La présente invention a trait à des inhibiteurs de diverses kinases (par exemple, les kinases S/T, les kinases Tyr et autres), lesdits inhibiteurs étant précédemment connus comme inhibiteur de la kinase dépendante des cyclines (CDK). Les inhibiteurs de la présente invention sont capables d'inhiber diverses kinases de type sauvage et de formes mutantes, y compris les formes de kinases mutantes résistantes aux médicaments. Donc les inhibiteurs de kinase de l'invention sont utiles dans le traitement d'une large gamme de maladies/conditions associées aux fonctions anormales/activités excessives des kinases cibles, y compris des kinases mutantes. L'invention a trait en outre à des procédés pour le traitement des cancers, tumeurs et de patients qui sont résistants ou réfractaires à d'autres agents thérapeutiques. L'invention a également trait à des compositions pharmaceutiques et des produits pharmaceutiques emballés avec des modes d'emploi desdits inhibiteurs, et à des procédés d'utilisation desdits inhibiteurs.
Caligiuri Maureen G.
Kley Nikolai A.
Murthi Krishna K.
Agennix Usa Inc.
Borden Ladner Gervais Llp
Gpc Biotech Inc.
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