Kinase inhibitors useful for the treatment of...

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 413/14 (2006.01) A61K 31/4427 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2684666

Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant, melanomas, glioblastomas, ovarian cancer, pancreatic cancer, prostate cancer, lung cancers, breast cancers, kidney cancers, cervical carcinomas, metastasis of primary tumor sites, myeloproliferative diseases, leukemias, papillary thyroid carcinoma, non small cell lung cancer, mesothelioma, hypereosinophilic syndrome, gastrointestinal stromal tumors, colonic cancers, ocular diseases characterized by hyperproliferation leading to blindness including various retinopathies, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, mastocytosis, mast cell leukemia, a disease caused by c-Abl kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof, or a disease caused by c-Kit kinase, oncogenic forms thereof, aberrant fusion proteins thereof and polymorphs thereof.

La présente invention concerne des composés utiles dans le traitement des cancers des mammifères et en particulier des cancers humains y compris, mais sans limitation, des tumeurs malignes, des mélanomes, des glioblastomes, du cancer des ovaires, du cancer du pancréas, du cancer de la prostate, des cancers des poumons, des cancers du sein, des cancers des reins, des cancers du col de l'utérus, des métastases des sites tumoraux principaux, des maladies myéloprolifératives, des leucémies, des carcinomes papillaires de la thyroïde, du cancer bronchique à petites cellules, du mésothéliome, du syndrome hyperéosinophile, des tumeurs stromales digestives, des cancers du colon, des maladies oculaires caractérisées par une hyperprolifération aboutissant à une perte de la vue, y compris une variété de rétinopathies, de l'arthrite rhumatoïde, de l'asthme, de la maladie pulmonaire chronique obstructive, de la mastocytose, de la leucémie des mastocytes, d'une maladie causée par la kinase c-Abl, des formes oncogéniques de cette maladie, des protéines de fusion aberrantes de celles-ci et leurs polymorphes ou d'une maladie causée par la kinase c-Kit, leurs formes oncogéniques, leurs protéines aberrantes et leurs polymorphes.

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