C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 487/04 (2006.01) A61K 31/519 (2006.01) C07D 471/04 (2006.01)
Patent
CA 2664009
The present invention relates to novel kinase inhibitors and modulator compounds useful for the treatment of various diseases. More particularly, the invention is concerned with such compounds, kinase/compound adducts, methods of treating diseases, and methods of synthesis of the compounds. Preferrably, the compounds are useful for the modulation of kinase activity of Raf kinases and disease polymorphs thereof. Compounds of the present invention find utility in the treatment of mammalian cancers and especially human cancers including but not limited to malignant melanoma, colorectal cancer, ovarian cancer, papillary thyroid carcinoma, non small cell lung cancer, and mesothelioma. Compounds of the present invention also find utility in the treatment of rheumatoid arthritis and retinopathies including diabetic retinal neuropathy and macular degeneration.
La présente invention concerne de nouveaux inhibiteurs de la kinase et des composés modulateurs utiles dans le traitement de diverses maladies. Plus particulièrement, l'invention concerne de tels composés, des adduits composé/kinase, des procédés permettant de traiter des maladies, et des procédés de synthèse de ces composés. De préférence, lesdits composés sont utiles pour la modulation de l'activité kinasique des kinases Raf et des polymorphes de maladies de celles-ci. Les composés de la présente invention sont utiles dans le traitement de cancers touchant des mammifères, en particulier de cancers affectant l'Homme et comprenant, sans s'y limiter, le mélanome malin, le cancer colorectal, le cancer des ovaires, le carcinome thyroïdien papillaire, le cancer du poumon à grandes cellules, et le mésothéliome. Les composés de la présente invention sont également utiles dans le traitement de l'arthrite rhumatoïde et des rétinopathies incluant la neuropathie rétinienne diabétique et la dégénérescence maculaire.
Flynn Daniel L.
Kaufman Michael D.
Patt William C.
Petillo Peter A.
Deciphera Pharmaceuticals Llc
Gowling Lafleur Henderson Llp
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