Kinase inhibitors with improved cyp safety profile

Details Kinase inhibitors with improved cyp safety profile Kinase inhibitors with improved cyp safety profile

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4365 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2743592

Compounds that inhibit protein kinases such as Aurora-kinases and the VEGFR and PDGFR families of kinases, with an improved safety profile due to low CYP3A4 inhibition, compositions containing the compounds and methods of treating diseases using the compounds are disclosed.

La présente invention porte sur des composés qui inhibent des protéines kinases telles que des Aurora-kinases et les familles VEGFR et PDGFR de kinases, dont le profil d'innocuité est amélioré en raison d'une inhibition faible de CYP3A4, sur des compositions contenant les composés et sur des méthodes de traitement de maladies à l'aide des composés.

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