C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 401/14 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61K 31/4545 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01) C07D 403/14 (2006.01) C07D 413/14 (2006.01) C07D 471/08 (2006.01)
Patent
CA 2506546
The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides oxindole derivatives which inhibit, regulate and/or modulate kinase receptor, particularly VEGF receptor 2 (Flk- 1/KDR), FGFR1, and PDGFR (alpha and beta), signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase- dependent diseases and conditions.
La présente invention concerne des composés servant à moduler l'activité enzymatique de la protéine kinase afin que les activités cellulaires, telles que la prolifération, la différenciation, la mort cellulaire programmée, la migration et la chimio-invasion, soient modulées. Cette invention concerne de manière plus spécifique des dérivés oxindole qui inhibent, régulent et/ou modulent le récepteur de la kinase, en particulier le récepteur 2 du VEGF (Flk-1/KDR), le FGFR1 et le PDGFR (alpha et bêta), des voies de transduction de signal associées aux variations des activités cellulaires telles que mentionnées plus haut, des compositions contenant ces composés ainsi que des procédés d'utilisation de ces composés pour traiter les maladies et états pathologiques dépendant de la kinase.
Bannen Lynne Canne
Brown S. David
Cheng Wei
Co Erick Wang
Kim Moon Hwan
Bennett Jones Llp
Exelixis Inc.
Symphony Evolution Inc.
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