C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2729219
Tyrosine kinase substrates are described herein that are phosphorylated by many and diverse tyrosine kinases, and are chemically stable relative to co-polymers of poly-EY or poly-EAY having random molecular weights in the range of 20-50 kDa. Tyrosine kinase substrate peptides are provided according to embodiments described herein which include an isolated tyrosine kinase substrate peptide having molecular weight in the range of about 0.5 kD - 10 kD. Tyrosine kinase substrate peptides are provided according to embodiments described herein having no more than 50 amino acids. The peptides include 2 - 25 phosphorylation modules and each phosphorylation module has 2-3 amino acid residues.
La présente invention concerne des substrats de tyrosine kinases qui sont phosphorylés par des tyrosine kinases nombreuses et variées, et qui sont chimiquement stables par rapport à des copolymères poly-EY ou poly-EAY ayant des poids moléculaires sous forme statistique variant de 20 à 50 kDa. Selon des modes de réalisation, les peptides substrats de tyrosine kinase de linvention comprennent un peptide substrat de tyrosine kinase isolé ayant un poids moléculaire variant denviron 0,5 kD à 10 kD. Selon des modes de réalisation, les peptides substrats de tyrosine kinase de linvention ne présentent pas plus de 50 acides aminés. Les peptides comprennent de 2 à 25 modules de phosphorylation et chaque module de phosphorylation présente 2-3 résidus dacide aminé.
Beaudet Lucille
Blouin Julie
Roby Philippe
Perkinelmer Health Sciences Inc.
Ridout & Maybee Llp
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