Kinase suppressor of ras inactivation for therapy of ras...

C - Chemistry – Metallurgy – 07 – H

Patent

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C07H 21/02 (2006.01) A01N 63/00 (2006.01) C07H 21/04 (2006.01) C12N 5/00 (2006.01) C12N 15/00 (2006.01) C12N 15/11 (2006.01) C12N 15/63 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2488048

The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided.

La présente invention porte sur des procédés et sur des compositions destinés à l'inhibition spécifique du suppresseur kinase de Ras (KSR). Cette invention porte notamment sur des méthodes génétiques et sur des acides nucléiques destinés à l'inhibition spécifique de KSR, en particulier de l'expression de KSR. L'invention porte, en outre, sur des oligonucléotides antisens et sur l'expression de l'acide nucléique qui est sensiblement complémentaire à l'ARN de KSR. L'invention porte aussi sur des compositions d'oligonucléotides et d'acides nucléiques. L'invention porte sur des procédés visant à inhiber KSR, tels que l'inhibition de l'expression de KSR, sur des procédés visant à bloquer la tumorigénèse induite par gf Ras, la métastase et sur des procédés de traitement anticancéreux.

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