C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 31/7088 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07H 21/00 (2006.01) C07H 21/02 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 9/22 (2006.01) C12N 15/63 (2006.01) C12Q 1/02 (2006.01) C12Q 1/68 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2549384
The present invention relates to methods and compositions for the specific inhibition of kinase suppressor of Ras (KSR). In particular, the invention provides genetic approaches and nucleic acids for the specific inhibition of KSR, particularly of KSR expression. The invention relates to antisense oligonucleotides and the expression of nucleic acid which is substantially complementary to KSR RNA. Oligonucleotide and nucleic acid compositions are provided. The invention provides methods to inhibit KSR, including inhibition of KSR expression. Methods for blocking gf Ras mediated tumorigenesis, metastasis, and for cancer therapy are provided. Methods for conferring radiosensitivity to cells are also provided.
L'invention concerne des procédés et des compositions destinés à l'inhibition spécifique d'un suppresseur de kinase de Ras (KSR). Plus précisément, l'invention concerne des approches génétiques et des acides nucléiques destinés à l'inhibition spécifique de KSR, notamment de l'expression de KSR. L'invention concerne également des oligonucléotides antisens et l'expression d'acide nucléique sensiblement complémentaire à l'ARN de KSR. L'invention concerne, en outre, des compostions d'oligonucléotides et d'acide nucléique. L'invention concerne enfin des procédés d'inhibition de KSR, notamment l'inhibition de l'expression de KSR et des procédés permettant de bloquer des tumorigénèses et des métastases induites par <i>gf</i> Ras et destinés à la cancérothérapie, ainsi que des procédés permettant de conférer une radiosensibilité à des cellules.
Kolesncik Richard N.
Xing Hongmei R.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Memorial Sloan-Kettering Cancer Center
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