Kit and method for pretargeting

Details Kit and method for pretargeting Kit and method for pretargeting

A - Human Necessities

61

K

A61K 49/00 (2006.01) A61K 39/395 (2006.01) A61K 47/42 (2006.01) A61K 47/48 (2006.01) A61K 51/00 (2006.01) C07K 7/06 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01) G01N 33/577 (2006.01) G01N 33/60 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2126819

ABSTRACT The invention describes a novel kit or method for the delivery of pharmaceutical or diagnostic compounds to target cells in the body. This kit comprises a monospecific antibody with multiple binding sites, which antibody recognizes a target associated antigen, and a ligand-effector moiety, of which the ligand has been derived from the target associated antigen or analogue thereof. Specifically the invention relates to targeting cytotoxic drugs or radioisotopes to tumor cells. The preferred antibody is a human IgM and the ligand is preferably the epitope cognate to said antibody.

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