Kit and method for the labelling of biomolecules

Details Kit and method for the labelling of biomolecules Kit and method for the labelling of biomolecules

G - Physics

01

N

G01N 1/28 (2006.01) C09K 11/07 (2006.01) G01N 33/52 (2006.01) C09B 62/00 (2006.01)

Patent

CA 2718205

The present invention relates to a kit for the labelling of biomolecules bearing reactive amino or hydroxyl groups. The kit consists of a Reagent A and a Reagent B, individually packaged, comprising: a mixture of a carboxylated labelling compound and a tertiary amine (Reagent A); and a coupling reagent (Reagent B). Upon contacting Reagent A with Reagent B, the carboxylated labelling compound is activated in-situ by the coupling reagent (a guanidinium, or uronium salt) in the presence of the tertiary amine. The active form of the carboxylated labelling compound is reacted with a biomolecules bearing reactive amino or hydroxyl groups, with formation of a stable covalent bond between the carboxylated labelling compound and the biomolecule.

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