Klebsiella capsular polysaccharide vaccine

Details Klebsiella capsular polysaccharide vaccine Klebsiella capsular polysaccharide vaccine

A - Human Necessities

61

K

167/135

A61K 39/108 (2006.01)

Patent

CA 1263308

Abstract The present invention relates to immunogenic preparations of Klebsiella species serotype-specific capsular polysaccharides. The invention involves the treatment of Klebsiella capsular polysaccharides in dilute sodium hydroxide to detoxify co-purified toxic lipopolysaccharides and to yield immunogenic vaccine preparations safe for parenteral administration to humans. The polyvalent vaccines prepared by use of the above vaccine are effective at providing protection against infections caused by Klebsiella species bacilli.

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