C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2579034
Disclosed are methods of identifying and diagnosing certain types of cancers and pre-stages thereof in a patient by identifying alternatively spliced isoforms of wild type KLF6 (KLFwt), in particular anyone of the isoforms selected from the group consisting of: KLF6 splice variant-1 (KLF6SV1), KLF6 splice variant-2 (KLF6SV2), and KLF6 splice variant-3 (KLF6SV3). Also disclosed are methods diagnosising cancer using the polypeptides and polynucleotides identified herein, as well as methods of treating certain types of cancers by inhibiting polynucleotides and polypeptides identified herein.
L'invention concerne des méthodes d'identification et de diagnostic de certains types de cancers et de leurs phases préliminaires chez un patient consistant à identifier des isoformes épissées de manière alternative de KLF6 de type sauvage (KLFwt), en particulier n'importe laquelle des isoformes sélectionnées dans le groupe contenant: variant-1 d'épissure de KLF6 (KLF6SV1), variant-2 d'épissure de KLF6 (KLF6SV2), et variant-3 d'épissure de KLF6 (KLF6SV3). L'invention concerne également des méthodes de diagnostic du cancer utilisant les polypeptides et les polynucléotides identifiés ici, de même que des méthodes de traitement de certains types de cancers par inhibition des polynucléotides et des polypeptides identifiés ici.
Friedman Scott
Martignetti John
Narla Goutham
Mount Sinai School Of Medicine Of New York University
Robic
LandOfFree
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