Knock-in mouse prostate cancer model

Details Knock-in mouse prostate cancer model Knock-in mouse prostate cancer model

C - Chemistry, Metallurgy

12

N

C12N 15/11 (2006.01) A01K 67/00 (2006.01) C07K 14/82 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01) C12N 15/90 (2006.01)

Patent

CA 2411729

A number of transgenic mouse adenocarcinoma prostate cancer models have been established. However, all previous models use a histological grading system which is not clinically applicable. In view of these limitations a knock-in mouse adenocarcinoma prostate model (KIMAP) was developed. This model was established by targeting the PSP94 gene with a tumor-inducer gene (SV40 Tag). The KIMAP model shows the applicability of the Gleason histological grading system, which is widely used in the clinical diagnosis and prognosis of human prostate cancer. Our evaluation indicates that the KIMAP model meets requirements for a new standard murine model for both basic and clinical studies of prostate cancer.

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