Knockout nonhuman animal

Details Knockout nonhuman animal Knockout nonhuman animal

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A01K 67/027 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12Q 1/68 (2006.01) G01N 33/15 (2006.01) G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2576415

A knockout nonhuman animal having at least one disrupted allele in PHF3 gene in the genome thereof which is useful in, for example, developing drugs for diseases accompanied by the onset of atopic dermatitis; a totipotent cell such as an ES cell essentially required in constructing the above nonhuman animal; utilization thereof; and so on.

Animal non-humain assommé ayant au moins un allèle disloqué dans le gène PHF3 du génome qui est utile, par exemple, pour le développement de médicaments pour des maladies accompagnées d'un début d'eczéma atopique; une cellule totipotente telle qu'une cellule ES essentiellement nécessaire dans la constitution de l'animal non-humain assommé précité; son utilisation; et ainsi de suite.

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