Knockout swine and methods for making the same

Details Knockout swine and methods for making the same Knockout swine and methods for making the same

A - Human Necessities

01

K

A01K 67/00 (2006.01) A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 9/10 (2006.01) C12N 15/00 (2006.01) C12N 15/06 (2006.01) C12N 15/09 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2471035

The invention relates to the genetic manipulation of non-human animals. More particularly, the invention relates to genetic manipulation of non-human animals to be used for xenotransplantation. The invention provides viable gene knockout swine including swine in which the .alpha.(1,3)-galactosyltransferase gene has been disrupted, methods for making such swine, and methods of using the tissues and organs of such swine for xenotransplantation.

L'invention concerne la manipulation génétique d'animaux non humains. D'une manière plus spécifique, l'invention concerne la manipulation génétique d'animaux non humains destinés à être utilisés pour une xénotransplantation. L'invention permet d'obtenir un porc knoc-kout viable, notamment un porc dans lequel un gène .alpha.(1,3)-galactosyltransférase a été disloqué, des méthodes de fabrication de ce porc et des méthodes d'utilisation des tissus et organes dudit porc aux fins de la xénotransplantation.

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