Kunitz domain library

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/33 (2006.01) C12N 15/10 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2512590

Disclosed are libraries, vectors, phage particles, host cells, and methods for displaying a Kunitz domain. The libraries can include Kunitz domains that vary in at least two interaction loops with respect to one another. Varied Kunitz domains can be displayed on phage at a low valency.

L'invention concerne des librairies, des vecteurs, des particules phages, des cellules hôtes et des procédés relatifs à la présentation d'un domaine de Kunitz. Les librairies peuvent comprendre des domaines de Kunitz qui varient mutuellement au moins dans deux boucles d'interaction. Les domaines de Kunitz soumis à cette variation peuvent être présentés sur un phage à faible valence.

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