Kunitz type plasma kallikrein inhibitors

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/15 (2006.01) A61K 38/57 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2220130

Potent and specific serine protease inhibitors are provided that are capable of inhibiting plasma kallikrein. The inhibitors comprise a non-native Kunitz type serine protease inhibitor domain. The inhibitors are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of plasma kallikrein is indicated.

La présente invention concerne des inhibiteurs puissants et ciblés de protéase sérique, pouvant inhiber la kallicréine plasmique. Ces inhibiteurs comprennent un domaine inhibiteur de protéase sérique de type Kunitz non natif. Ces inhibiteurs se présentent sous forme de compositions pharmaceutiques convenant au traitement des affections et des troubles pour lesquels l'inhibition de la kallicréine plasmique est indiquée.

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