Kuz, a novel family of metalloproteases

Details Kuz, a novel family of metalloproteases Kuz, a novel family of metalloproteases

C - Chemistry, Metallurgy

12

N

C12N 15/57 (2006.01) A01K 67/027 (2006.01) A61K 38/48 (2006.01) A61K 39/395 (2006.01) C12N 9/64 (2006.01) C12Q 1/37 (2006.01)

Patent

CA 2263883

Members of a novel family of polypeptides, the KUZ family, are metalloproteases involed in neuronal partitioning and neuronal development. The invention provides KUZ polypeptides, antibodies that bind the KUZ plypeptides, KUZ encoding nucleic acids, methods for identifying cells expressing the KUZ polypeptides, methods of identifying ligands that bind to the subject proteins and methods of blocking KUZ polypeptide/ligand interactions.

L'invention concerne des membres d'une nouvelle famille de polypeptides, la famille KUZ, à savoir des métalloprotéases participant à la séparation neuronale et au développement neuronal. L'invention concerne des polypeptides KUZ, des anticorps qui fixent les polypeptides KUZ, des acides nucléiques qui codent les KUZ, des méthodes pour identifier des cellules exprimant les polypeptides KUZ, des méthodes pour identifier des ligands qui fixent les protéines concernées, ainsi que des méthodes pour bloquer les interactions polypeptides KUZ/ligands.

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