Kv1.5-blocker for the selective increase of atrial...

A - Human Necessities – 61 – K

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A61K 31/4406 (2006.01) A61K 31/166 (2006.01) A61K 31/44 (2006.01) A61P 9/04 (2006.01)

Patent

CA 2557263

The invention relates to the contractility-increasing action of Kvl.5- blockers, especially phenylcarboxylic acid amides of formulae la and/or lb (I), (II) and/or pharmaceutically acceptable salts thereof, for treating reduced atrial contractility and cardiac insufficiency, especially cardiac insufficiency caused by diastolic dysfunction.

L'invention concerne l'effet de contractilité de l'oreillette exercé par des KvI.5-bloquants, en particulier, des amides de l'acide phénylcarboxylique de formules Ia et/ou Ib (I), (II), et/ou des sels pharmaceutiquement acceptables de ceux-ci, pour le traitement de la contractilité atriale réduite et de l'insuffisance cardiaque, en particulier, de l'insuffisance cardiaque provoquée par un dysfonctionnement diastolique.

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