Kv1.5 potassium channel inhibitors

Details Kv1.5 potassium channel inhibitors Kv1.5 potassium channel inhibitors

C - Chemistry, Metallurgy

07

D

C07D 471/10 (2006.01) A61K 31/505 (2006.01) A61P 9/06 (2006.01)

Patent

CA 2654262

The present invention relates to 4-oxo-1,3,8-triaza-spiro[4.5]decanes which are useful as Kv1.5 potassium channel inhibitors providing atrial-selective antiarrhythmic activity. The present invention further relates to compositions and methods for treating atrial-selective antiarrhythmia.

la présente invention concerne des 4-oxo-1,3,8-triaza-spiro[4.5]décanes convenant comme inhibiteurs du canal potassique Kv1.5 du fait qu'ils exercent une activité anti-arythmique à sélectivité auriculaire. De plus, cette invention concerne des compositions et une méthode de traitement anti-arythmie à sélectivité auriculaire.

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