Kv10.1, a novel voltage-gated potassium channel from human...

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12N 15/64 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/567 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2370572

The invention provides isolated nucleic acid and amino acid sequences of Slo potassium family members such as , antibodies to Kv10 subfamily members such as Kv10.1, methods of detecting Kv10, subfamily members such as Kv10.1, methods of screening for potassium channel activators and inhibitors using biologically active Kv10 subfamily members such as Kv10.1, and kits for screening for activators and inhibitors of voltage-gated potassium channels comprising Kv10 subfamily members such as Kv10.1.

La présente invention concerne un acide nucléique isolé et des séquences d'aminoacides des membres de la famille du canal potassique Slo tels que: des anticorps aux membres de la sous-famille de Kv10 tels le Kv10.1, des procédés de détection de Kv10, des membres de la sous-famille tels le Kv10.1, des procédés de criblage des activateurs et des inhibiteurs du canal potassique mettant en oeuvre des membres de la sous-famille de Kv10, tels le Kv10.1, et des trousses pour le criblage des activateurs et des inhibiteurs de canaux potassiques commandés par tension comprenant des membres de la sous-famille de Kv10, tels le Kv10.1.

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