Kw-3902 conjugates that do not cross the blood-brain barrier

C - Chemistry – Metallurgy – 07 – D

Patent

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C07D 473/06 (2006.01) A61K 31/522 (2006.01) C07D 473/04 (2006.01) A61P 7/10 (2006.01) A61P 13/12 (2006.01)

Patent

CA 2661044

The present invention relates to certain compounds and to methods for the preparation of certain compounds that can be used in the fields of chemistry and medicine. Specifically, described herein are methods for the preparation of various compounds and intermediates, and the compounds and intermediates themselves. More specifically, described herein are methods for synthesizing KW-3902 derivatives of Formula (I), (II), (HI), (IV), (V), and (VI).

La présente invention concerne certains composés et des procédés servant à la préparation de certains composés pouvant être utilisés dans les domaines de la chimie et de la médecine. De façon spécifique, l'invention concerne des procédés servant à la préparation de divers composés et intermédiaires, ainsi que les composés intermédiaires eux-mêmes. Plus spécifiquement, l'invention concerne des procédés servant à synthétiser des dérivés KW-3902 représentés par les Formules (I), (II), (HI), (IV), (V) et (VI).

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