L',2',-diacyl-(6r,s)-5,6,7,8,-tetrahydro-l-biopterin and...

Details L',2',-diacyl-(6r,s)-5,6,7,8,-tetrahydro-l-biopterin and... L',2',-diacyl-(6r,s)-5,6,7,8,-tetrahydro-l-biopterin and...

C - Chemistry, Metallurgy

07

D

260/242.1

C07D 475/02 (2006.01) C07D 475/04 (2006.01)

Patent

CA 1208218

Abstract of the Invention A novel compound, 1',2'-diacyl-(6R,S)-5,6,7,8- tetrahydro-L-biopterin which is prepared by catalytical hydrogenation of a 1',2'-diacyl-L-biopterin in a solvent in the presence of a catalyst. The 1',2'-diacyl-L- biopterin is prepared from a 1,1-dialkylsulfonyl-L- rhamnose through an acyl derivative of 5-deoxy-L-arabinose and a hydrazine derivative of tetrahydro-L-biopterin without isolating the intermediate products. The 1',2'- diacyl-(6R,S)-5,6,7,8-tetrahydro-L-biopterin can be used for treatment of atypical phenylketonuria or dihydrop- terin-reductase deficiency and can readily cross the blood brain barrier without neurotransmitter precursors.

415245

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