C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 405/04 (2006.01) A61K 31/505 (2006.01) A61K 31/513 (2006.01) A61K 31/70 (2006.01) C07H 19/10 (2006.01) C07D 473/00 (2006.01)
Patent
CA 2272404
The present invention relates to the discovery that certain .beta.-L-dioxolane nucleoside analogs which contain a uracil base, and preferably, a 5- halosubstituted uracil base, exhibit unexpectedly high activity against Epstein-Barr virus (EBV), Varicella-Zoster virus (VZV) and Human Herpes Virus 8 (HV-8). In particular, the compounds according to the present invention show potent inhibition of the replication of the virus (viral growth) in combination with very low toxicity to the host cells (i.e., animal or human tissue). Compounds are useful for treating EBV, VZV and HV-8 infections in humans.
La présente invention concerne la découverte selon laquelle certains analogues de nucléosides de L-.beta.-dioxolane contenant une base uracile, et de préférence, une base uracile 5-halogénosubstituée, présentent une activité élevée inattendue contre le virus Eptsein-Barr, l'herpèsvirus varicellae et le virus de l'herpès humain 8. Les composés de l'invention présente notamment une forte inhibition de la réplication du virus (croissance du virus) et une toxicité très faible vis-à-vis des cellules hôtes (c'est-à-dire, des tissus animaux ou humains). Ces composés sont utiles pour traiter le virus Epstein-Barr, l'herpèsvirus varicellae et les infection dues à l'herpèsvirus 8 chez les humains.
Cheng Yung-Chi
Chu Chung K.
Qu Fucheng
Cassan Maclean
The University Of Georgia Research Foundation Inc.
Yale University
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