L-histidine in ophthalmic solutions

A - Human Necessities – 61 – K

Patent

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Details

A61K 31/74 (2006.01) A61K 9/00 (2006.01) A61K 31/415 (2006.01) A61K 31/4172 (2006.01) A61K 31/4415 (2006.01) A61K 33/40 (2006.01) A61K 47/32 (2006.01) A61L 12/08 (2006.01) A61L 12/10 (2006.01) A61L 12/12 (2006.01) A61L 12/14 (2006.01) A61K 47/18 (2006.01)

Patent

CA 2434961

The invention relates to an aqueous ophthalmic solution comprising 0.01 to about 1.0 percent by weight L-histidine; 0.01 to 0.0001 percent by weight hydrogen peroxide; 0.1 to 500 parts per million of a cationic polymeric preservative that provides superior preservative efficacy especially as against fungal microbes. These solutions may be employed in various ways including cleaning contact lenses, rinsing lenses while in the eye, storing lenses and in delivering active pharmaceutical agents to the eye.

L'invention concerne une solution ophtalmique aqueuse contenant 0,01 à 1 % en poids de L-histidine, 0,01 à 0,0001 % en poids de peroxyde d'hydrogène et 0,1 à 500 parties par million de conservateur polymère cationique conférant une efficacité de conservation supérieure et, en particulier, de protection contre les microbes fongiques. On peut utiliser ces solutions de différentes façons, y compris le nettoyage de lentilles de contact, le rinçage de ces lentilles pendant leur présence sur l'oeil, leur conservation ou l'administration d'agents pharmaceutiques actifs dans l'oeil.

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