L-n-n propyl-pipecolic acid-2,6-xylidide and method for...

Details L-n-n propyl-pipecolic acid-2,6-xylidide and method for... L-n-n propyl-pipecolic acid-2,6-xylidide and method for...

C - Chemistry, Metallurgy

07

D

260/292.8

C07D 211/60 (2006.01)

Patent

CA 1217773

L-N-n-PROPYLPIPECOLIC ACID-2,6-XYLIDIDE AND METHOD FOR PREPARING THE SAME Abstract The local anesthetic, L-N-n-propylpipecolic acid- 2,6-xylidide, namely: Image This compound is prepared by chlorinating L-pipecolic acid to yield the acid chloride, namely L-pipecolic acid chloride. The acid chloride is then reacted with 2,6-xylidine to yield L-pipecolic acid-2,6-xylidide. The L-N-pipecolic acid-2,6-xylidide is then propylated to yield the L-N- n-propylpipecolic acid-2,6-xylidide, which is a potent local anesthetic for mammals including man and is of rela- tively low toxicity.

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