L-ornithine phenyl acetate and methods of making thereof

Details L-ornithine phenyl acetate and methods of making thereof L-ornithine phenyl acetate and methods of making thereof

A - Human Necessities

61

K

A61K 31/198 (2006.01) A61K 31/192 (2006.01) A61P 1/16 (2006.01) C07C 227/18 (2006.01) C07C 57/32 (2006.01) C07C 229/26 (2006.01)

Patent

CA 2757373

Disclosed herein are crystalline forms of L-ornithine phenyl acetate and methods of making the same. The crystalline form may, in some embodiments, be Forms I, II, III and V, or mixtures thereof. The crystalline forms may be formulated for treating subjects with liver disorders, such as hepatic encephalopathy. Accordingly, some embodiments include formulations and methods of administering L-ornithine phenyl acetate.

La présente invention concerne des formes cristallines d'acétate de phényle L-ornithine et leurs procédés de fabrication. La forme cristalline peut, dans certains modes de réalisation, être les formes I, II, III et V, ou leurs mélanges. Les formes cristallines peuvent être formulées pour traiter des sujets atteints de troubles hépatiques tels que l'encéphalopathie hépatique. En conséquence, certains modes de réalisation comprennent des formulations et des méthodes d'administration de l'acétate de phényle L-ornithine.

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