L-selectin cleavage site, methods of diagnosis and usage...

Details L-selectin cleavage site, methods of diagnosis and usage... L-selectin cleavage site, methods of diagnosis and usage...

C - Chemistry, Metallurgy

12

N

C12N 9/50 (2006.01) A61K 38/02 (2006.01) A61K 38/16 (2006.01) A61K 39/395 (2006.01) C07K 2/00 (2006.01) C07K 14/00 (2006.01) C07K 14/705 (2006.01) C07K 16/18 (2006.01) C07K 16/28 (2006.01) C12Q 1/37 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2134317

ABSTRACT OF THE INVENTION The present invention discloses the cleavage sequence within L-selectin that becomes cleaved during neutrophil activation/stimulation. A previously unidentified approximately 6 kd L-selectin species, which remains associated with the activated/stimulated neutrophil, is also described. Based on these observation, the present invention provides methods of detecting L-selectin cleavage and methods of reducing the severity of biological responses associated with L-selectin cleavage.

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