Labeled chemotactic peptides to image focal sites of...

C - Chemistry – Metallurgy – 07 – K

Patent

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Details

C07K 7/06 (2006.01) A61K 38/06 (2006.01) A61K 38/07 (2006.01) A61K 38/08 (2006.01) A61K 49/00 (2006.01) A61K 51/08 (2006.01) C07K 1/13 (2006.01) C07K 5/08 (2006.01) C07K 5/083 (2006.01) C07K 5/10 (2006.01) C07K 5/103 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2173972

This invention relates to a method of detecting a site of infection or inflammation, and a method for treating such infection or inflammation, in an individual by administering to the individual a diagnostically or therapeutically effective amount of detectably labeled, therapeutic, or therapeutically-conjugated, chemotactic peptide that accumulates substantially at the infected or inflamed site, said chemotactic peptide having the general structure X—Y—Leu—Phe—[Z]n—W wherein X is an amino protecting group, Y is an amino acid residue, Z is a spacer sequence, n is 0 or 1, and W is a labeling or attachment substituent.

L'invention concerne un procédé pour détecter un site d'infection ou d'inflammation et une méthode pour traiter une telle infection ou inflammation chez un individu, en lui administrant une quantité suffisante pour les besoins du diagnostic ou du traitement, d'un peptide chimiotactique qui est marqué, ou qui est conjugué avec une substance thérapeutique. Ce peptide chimiotactique se concentre au niveau du site de l'infection ou de l'inflammation et il a la structure générale suivante X—Y—Leu—Phe—[Z]¿n?—W. Dans cette formule: X est un groupe amino protecteur, Y est un résidu aminoacide, Z est une séquence d'espacement, n est égal à 0 ou à 1 et W est un substituant de marquage ou de fixation.

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