Labelled ascorbic acid derivatives

Details Labelled ascorbic acid derivatives Labelled ascorbic acid derivatives

A - Human Necessities

61

K

A61K 51/04 (2006.01) A61K 49/00 (2006.01) A61K 49/06 (2006.01) A61K 49/08 (2006.01)

Patent

CA 2394959

Compounds of formula (I) where: X1 is OH or SH or NH2 or-L-Z; X2 and X3 are the same or different and each is H, C1-4 alkyl, benzyl, a protecting group or -L-Z, X4 is H or C1-4 alkyl, L is a linker comprising a chain of 0 - 10 atoms, Z is a group comprising a detectable moiety which comprise at least one detectable moiety are useful in the diagnosis and prognosis and radiotherapy of metastatic bone disease.

L'invention concerne des composés de formule (I) dans laquelle X?1¿ représente OH, SH, NH¿2? ou L-Z; X?2¿ et X?3¿ sont identiques ou différents et chacun représente H, alkyle C¿1-4?, benzyle, un groupe protecteur ou L-Z; X?4¿ représente H ou alkyle C¿1-4?, L représente un lieur comprenant de 0 à 10 atomes, Z représente un groupe comprenant une fraction détectable. Les composés comprennent au moins une fraction détectable, et sont utiles dans le diagnostic, le prognostic et la radiothérapie de la maladie osseuse métastatique.

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