Labelled glutamine and lysine analogues

Details Labelled glutamine and lysine analogues Labelled glutamine and lysine analogues

C - Chemistry, Metallurgy

07

K

C07K 14/81 (2006.01) A61K 49/14 (2006.01) A61K 51/08 (2006.01) C07K 7/06 (2006.01) C07K 7/08 (2006.01) C07K 14/00 (2006.01) C07K 14/33 (2006.01) C07K 14/47 (2006.01) C07K 14/78 (2006.01)

Patent

CA 2332277

Synthetic analogues of lysine and glutamine are provided which function as substrates for the fibrin-stabilising enzyme Factor XIIIa even when labelled with a detectable moiety. The use of suitable protecting groups provides compounds which possess reduced susceptibility to in vivo metabolism especially by peptidases, and are hence useful agents for the diagnosis of thrombosis, embolism, atherosclerosis, inflammation or cancer.

L'invention concerne des analogues synthétiques de lysine et de glutamine qui servent de substrats pour le facteur XIIIa, l'enzyme de stabilisation de la fibrine, même lorsqu'ils sont marqués à l'aide d'une fraction détectable. L'utilisation de groupes de protection appropriés permet d'obtenir des composés qui possèdent une sensibilité réduite à un métabolisme in vivo, notamment par des peptidases, et constituent de ce fait des agents utiles pour le diagnostic d'une thrombose, d'une embolie, d'une athérosclérose, d'une inflammation ou d'un cancer.

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