Labelled phospholipid spheres for organ visualization

G - Physics – 01 – T

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167/48

G01T 1/164 (2006.01) A61K 51/12 (2006.01)

Patent

CA 1100871

Labelled Phospholipid Spheres for Organ Visualization ABSTRACT OF THE DISCLOSURE A carrier is disclosed for diagnostic scanning agents labelled with short-lived radioisotopes for medical organ studies which comprises colloidally dispersed phospholipid material, and also disclosed are new diagnostic scanning agents utilizing the carrier and a radioisotope, preferably 99mTc, which is in a form which complexes with the carrier. The radioisotope labelling can be carried out directly before use, the carrier in dispersed form being stable for a considerable period of time. Methods of preparation of the scanning agents are also disclosed which provide a material which localizes mainly in the liver after injection, or alternately at least intially in the lungs when an aggregating agent is used during preparation in a specific sequence of steps. Specific organ scans or sequential scanning is thus possible.

241628

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