Labelling of nucleic acid analogue-peptide chimerae

Details Labelling of nucleic acid analogue-peptide chimerae Labelling of nucleic acid analogue-peptide chimerae

C - Chemistry, Metallurgy

07

K

C07K 2/00 (2006.01) C07H 21/00 (2006.01) C07K 1/13 (2006.01) C07K 14/00 (2006.01) C12Q 1/68 (2006.01) G01N 33/533 (2006.01)

Patent

CA 2177604

A nucleic acid analogue of the PNA type is provided with a kemptide motif and radio-labelled by phosphorylation at a service residue in said motif to provide a radio-labelled nucleic acid analogue having a specific activity in excess of 1 x 105 cpm/µg 32P.

Un analogue d'acide nucléique du type acide nucléique peptidique (PNA) est doté d'un motif kemptide et marqué isotopiquement par phosphorylation au niveau d'un reste fonctionnel présent dans ledit motif pour produire un analogue d'acide nucléique marqué isotopiquement présentant une activité spécifique supérieure à 1 x 10?5¿ cpm/µg ?32¿p.

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